Fig. 1 · Structure
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GYY4137
H2S Donor
GYY4137 is a sustained-release hydrogen sulfide (H2S) donor. It exhibits vasodilatory, antihypertensive, and anti-inflammatory activities, making it valuable for cardiovascular research. Additionally, GYY4137 demonstrates significant anticancer effects by inhibiting cell proliferation, inducing apoptosis, and causing cell cycle arrest through the blockade of the STAT3 signaling pathway. This compound is useful in studies exploring both cancer therapies and the physiological roles of H2S in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 106740-09-4 |
| Applications | H2S Donor |
| Formula | C15H25N2O3PS2 |
| Molecular Weight | 376.47 |
| SMILES | SP(N1CCOCC1)(C2=CC=C(OC)C=C2)=S.N3CCOCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.