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H052

Hla Inhibitor

H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla), effectively disrupting the interaction between Hla monomers and host cell membranes. By blocking pore formation, H052 inhibits calcium ion influx, cytotoxicity, and subsequent inflammatory responses. With a reported potency of EC50 = 30 nM in U937 cells, H052 serves as a valuable tool for investigating lung infections caused by Staphylococcus aureus. Its unique mechanism makes it relevant for research focusing on Hla-related pathogenesis and potential therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2886748-00-9
Applications	Hla Inhibitor
Formula	C₂₁H₁₅ClFN₃O₄S
Molecular Weight	459.88
SMILES	O=C1NC2=C(C=C(C)C(S(NC3=CC=C(C4=CC=C(F)C=C4)C(Cl)=C3)(=O)=O)=C2)NC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.