Fig. 1 · Structure
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H111-H7
WWP2 Inhibitor
H111-H7 is a selective inhibitor of WWP2 (WW domain containing E3 ubiquitin protein ligase 2), exhibiting a KD of 717 nM. This compound is capable of inhibiting WWP2 expression, thereby restoring levels of succinate dehydrogenase complex subunit C (SDHC) and delaying the progression from acute kidney injury (AKI) to chronic kidney disease (CKD) in models of unilateral kidney ischemia–reperfusion (UIR). H111-H7 is valuable for research focused on elucidating the mechanisms underlying the AKI-to-CKD transition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 220965-54-8 |
| Applications | WWP2 Inhibitor |
| Formula | C13H10ClNO3S2 |
| Molecular Weight | 327.81 |
| SMILES | CC(C1=CC([N+]([O-])=O)=C(S1)SCC2=CC=C(C=C2)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.