Fig. 1 · Structure
Documents & Downloads
H3B-8800
SF3B Aplicing Modulator
H3B-8800 is a potent, orally active modulator of the SF3B spliceosome complex. It directly interacts with the SF3B complex and exhibits anti-cancer properties. H3B-8800 is particularly relevant for research on acute myeloid leukemia (AML) associated with SF3B1 mutations. Its ability to influence splicing pathways makes it a valuable tool for investigating therapeutic strategies targeting this oncogenic process.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1825302-42-8 |
| Applications | SF3B Aplicing Modulator |
| Formula | C31H45N3O6 |
| Molecular Weight | 555.71 |
| SMILES | O=C(N1CCN(C)CC1)O[C@H]([C@](C)(O)CC[C@@H](O)C2)/C=C/[C@H](C)[C@H](OC2=O)/C(C)=C/C=C/[C@@H](C)C3=NC=CC=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.