Fig. 1 · Structure
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H3B-968
WRN Inhibitor
H3B-968 is an ATP-competitive inhibitor of Werner syndrome protein (WRN), exhibiting an IC50 of approximately 10 nM. This compound effectively impedes the helicase activity of WRN, making it a valuable tool in research focused on DNA repair mechanisms and cellular aging. H3B-968 is applicable in studies related to genomic stability and the development of therapeutic strategies for disorders associated with WRN dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2912294-90-5 |
| Applications | WRN Inhibitor |
| Formula | C22H18F6N4O4S |
| Molecular Weight | 548.46 |
| SMILES | O=C(CNS(=O)(C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CC(C(F)(F)F)=N1)=O)NC3=CC=C(CC)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.