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H3R antagonist 8

H3R Antagonist

H3R antagonist 8 is a selective non-imidazole antagonist of the histamine H3 receptor, with an IC50 of 0.35 μM. This compound demonstrates significant hERG channel blockade activity (IC50 = 0.67 μM) and exhibits antiepileptic properties, effectively reducing tonic hind limb extension in the maximal electroshock seizure model in mice (ED50 = 20.21 mg/kg). Additionally, H3R antagonist 8 shortens the total movement distance in pentylenetetrazol-induced zebrafish larvae, making it a valuable reagent for epilepsy research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3097193-89-7
Applications	H3R Antagonist
Formula	C₂₃H₂₇ClN₂O₂
Molecular Weight	398.93
SMILES	CCN(CC)CCCOC1=CC=C(C2=C(C3=CC=CC=C3Cl)OC(C)=N2)C=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.