Fig. 1 · Structure
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HA-100 hydrochloride
Protein Kinase Inhibitor
HA-100 hydrochloride is a potent protein kinase inhibitor targeting cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC), and myosin light chain kinase (MLC-kinase) with IC50 values of 4 μM, 8 μM, 12 μM, and 240 μM, respectively. Additionally, it serves as a Rho-associated protein kinase (ROCK) inhibitor. This reagent is valuable in studying signal transduction pathways and investigating cellular processes such as migration, proliferation, and differentiation in various research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 141543-63-7 |
| Applications | Protein Kinase Inhibitor |
| Formula | C13H16ClN3O2S |
| Molecular Weight | 313.80 |
| SMILES | O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.