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Hakin-1

Hakai Inhibitor

Hakin-1 is a selective inhibitor of the E3 ubiquitin ligase Hakai. It effectively blocks Hakai-mediated global and specific ubiquitination of E-cadherin, leading to the inhibition of epithelial-mesenchymal transition (EMT). This compound has demonstrated potential in inhibiting tumor progression and cancer metastasis, making it a valuable tool for research in carcinomas, particularly colorectal cancer.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	346660-34-2
Applications	Hakai Inhibitor
Formula	C₁₆H₁₁N₅O₅S
Molecular Weight	385.35
SMILES	O=C(C1=CC=C(N2N=NN=C2SCC(C3=CC=C([N+]([O-])=O)C=C3)=O)C=C1)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.