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Handelin

Catalog No.: A79573
NF-κB Inhibitor
Handelin is a guaianolide dimer derived from Chrysanthemum boreale that acts as a potent inhibitor of NF-κB signaling. This compound effectively down-regulates the production of pro-inflammatory cytokines, demonstrating significant anti-inflammatory activity. Handelin is valuable for research applications focused on inflammation, immune response modulation, and related signaling pathways.
Handelin 62687-22-3 NF-κB Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$50.00
In stock
5mg
$145.00
In stock
10mg
$250.00
In stock
25mg
$415.00
In stock
50mg
$590.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHandelin is a guaianolide dimer derived from Chrysanthemum boreale that acts as a potent inhibitor of NF-κB signaling. This compound effectively down-regulates the production of pro-inflammatory cytokines, demonstrating significant anti-inflammatory activity. Handelin is valuable for research applications focused on inflammation, immune response modulation, and related signaling pathways.
Product Information
Catalog NumA79573
FormulaC32H40O8
Molecular Weight552.66
CAS Number62687-22-3
SMILESC[C@]([C@]([C@@](OC1=O)([H])[C@@](C1=C)([H])CC[C@]2(O)C)([H])[C@@]32C4)(C=C3)[C@]54[C@@]([C@H]6OC(C)=O)([H])[C@]([C@](C(C)=CC7)([H])[C@]7([H])[C@](C)(O)C6)([H])OC5=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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    C2

    V2

NF-κB/IκB > NF-κB