Fig. 1 · Structure
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HbF inducer 2
HbF Inducer
HbF Inducer 2 is an orally active molecular glue that targets the WIZ transcription factor, leading to its degradation (DC50=13 nM) and subsequent induction of fetal hemoglobin (HbF) expression (EC50=100 nM). This compound demonstrates favorable pharmacokinetic properties in preclinical models, including cynomolgus monkeys, making it a valuable tool for studying hematologic disorders. Its ability to enhance HbF levels presents potential applications in therapies for sickle cell disease and beta-thalassemia research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2654011-51-3 |
| Applications | HbF Inducer |
| Formula | C21H27N3O4 |
| Molecular Weight | 385.46 |
| SMILES | O=C(C(N(CC1=C2C=CC(OC[C@@H]3N(CC)CCCC3)=C1)C2=O)CC4)NC4=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.