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HBP08

CXCL12/HMGB1 Inhibitor

HBP08 is a selective inhibitor of the CXCL12/HMGB1 interaction, demonstrating a high affinity for HMGB1 with a Kd of 0.8 μM. This compound effectively inhibits CXCL12-mediated cell migration, making it a valuable tool for studying chemotaxis and cellular signaling pathways in various biological contexts. Its specificity and potency position HBP08 as a promising reagent for research applications focused on inflammatory responses and cancer biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2490442-13-0
Applications	CXCL12/HMGB1 Inhibitor
Formula	C₆₀H₇₇N₁₇O₁₄
Molecular Weight	1260.36
SMILES	C([C@@H](C(N[C@H](C(N[C@@H](CC1=CN=CN1)C(O)=O)=O)[C@H](CC)C)=O)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CC3=CN=CN3)NC([C@H](CC4=CC=C(O)C=C4)NC(CN)=O)=O)=O)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)C=5C=6C(NC5)=CC=CC6

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.