Fig. 1 · Structure
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HC-7366
GCN2 Activator
HC-7366 is a selective activator of the GCN2 kinase that effectively binds to the ATP pocket, demonstrating an IC50 of 72 nM. This binding induces conformational activation of GCN2, leading to the upregulation of key mediators in the integrated stress response pathway, such as ATF4 and ASNS, which contribute to its anti-tumor efficacy. Additionally, HC-7366 exhibits inhibitory activity against ZAK, with an IC50 of 47 nM, making it a valuable tool for investigating fibrosarcoma and acute myeloid leukemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2803470-63-3 |
| Applications | GCN2 Activator |
| Formula | C20H15ClF2N6O4S |
| Molecular Weight | 508.89 |
| Synonyms | GCN2 modulator-1 |
| SMILES | O=C(C1=C2C=NC(C3=C(C=CC(NS(=O)(C4=CC(Cl)=CN=C4OC)=O)=C3F)F)=CN2C=N1)NC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.