Fig. 1 · Structure
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hCA I-IN-2
hCA I Inhibitor
hCA I-IN-2 is a selective inhibitor of human carbonic anhydrase I (hCA I), exhibiting a Ki value of 18.8 nM for this target. It demonstrates considerable selectivity for hCA I over other isoforms, with Ki values of 375.1 nM for hCA II, 1721 nM for hCA IX, and 283.9 nM for hCA XII. This compound is valuable for research applications involving enzymatic regulation and the role of carbonic anhydrases in physiological and pathological processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2417232-12-1 |
| Applications | hCA I Inhibitor |
| Formula | C26H20BrN5O3S |
| Molecular Weight | 562.44 |
| SMILES | NS(=O)(C1=CC=C(C=C1)N2C=C(N=N2)CN3C=C(C4=CC=CC=C43)/C=C/C(C5=CC=C(C=C5)Br)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.