Fig. 1 · Structure
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hCA/Wnt/β-catenin-IN-1
hCA Inhibitor
hCA/Wnt/β-catenin-IN-1 is a potent inhibitor of human carbonic anhydrases (hCA II, hCA IX, hCA XII) with Ki values of 33.6, 24.1, and 6.8 nM, respectively. This compound effectively reduces P-glycoprotein (P-gp) activity and suppresses the Wnt/β-catenin signaling pathway. It has demonstrated significant inhibition of cancer cell viability, including in the NCI/ADR-RES doxorubicin-resistant cell line, making it a valuable tool for cancer research and the study of multidrug resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3032826-63-1 |
| Applications | hCA Inhibitor |
| Formula | C26H24N2O6S |
| Molecular Weight | 492.54 |
| SMILES | O=S(C1=CC=C(N2C=C(C3=CC=CC=C3)C(C(C4=CC(OC)=C(OC)C(OC)=C4)=O)=C2)C=C1)(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.