Fig. 1 · Structure
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hCAI/II-IN-3
hCA I/II Inhibitor
hCAI/II-IN-3 is a potent dual inhibitor of human carbonic anhydrases I and II, exhibiting Ki values of 51.25 nM for hCA I and 13.15 nM for hCA II, along with an affinity for hCA IX at 42.18 nM. This compound demonstrates significant anti-hypoxic activity, making it relevant for investigations into acute mountain sickness (AMS) and related hypoxic conditions. Its unique properties may facilitate research into therapeutic approaches for managing hypoxia-induced pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2480283-93-8 |
| Applications | hCA I/II Inhibitor |
| Formula | C16H18N4O4S2 |
| Molecular Weight | 394.47 |
| SMILES | O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)NC3CCCC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.