hCAII-IN-9 is a potent inhibitor of carbonic anhydrases, specifically exhibiting IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. This compound demonstrates significant potential for research applications related to the modulation of carbonic anhydrase activity in various physiological and pathological conditions. Notably, hCAII-IN-9 does not exhibit permeability across the blood-brain barrier, making it suitable for studies focused on peripheral rather than central effects.
hCAII-IN-9 is a potent inhibitor of carbonic anhydrases, specifically exhibiting IC50 values of 1.18 μM for hCA II, 0.17 μM for hCA IX, and 2.99 μM for hCA XII. This compound demonstrates significant potential for research applications related to the modulation of carbonic anhydrase activity in various physiological and pathological conditions. Notably, hCAII-IN-9 does not exhibit permeability across the blood-brain barrier, making it suitable for studies focused on peripheral rather than central effects.
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