Fig. 1 · Structure

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HCAIX-IN-1

HCAIX Inhibitor

HCAIX-IN-1 is a potent and selective inhibitor of carbonic anhydrase IX (HCAIX), exhibiting inhibition constants (KIs) of 694.9 nM, 126.6 nM, 3.3 nM, and 9.8 nM for human carbonic anhydrases I, II, IX, and XII, respectively. This compound demonstrates significant potential for research applications in cancer therapy, particularly in targeting tumor-associated HCAIX, which plays a role in tumor growth and metastasis. HCAIX-IN-1 can serve as a valuable tool for studies exploring the physiological roles of HCAIX and the development of novel therapeutic strategies.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 2389034-65-3
Applications HCAIX Inhibitor
Formula C16H17N7O4S
Molecular Weight 403.42
SMILES
COC1=CC=C(C=C1)NC(NC2=NN(C(N)=N2)C3=CC=C(C=C3)S(N)(=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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