Fig. 1 · Structure
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hCAIX-IN-12
hCAIX Inhibitor
hCAIX-IN-12 is a selective human carbonic anhydrase IX (hCAIX) inhibitor, demonstrating an IC50 of 0.74 μM for hCAIX and 10.78 μM for carbonic anhydrase II (CAII). This compound exhibits significant antiproliferative effects and promotes apoptosis in cancer cells, along with increasing reactive oxygen species (ROS) production. hCAIX-IN-12 is primarily utilized in research related to colorectal cancer (CRC), providing potential therapeutic insights into tumor growth regulation and oxidative stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2414598-85-7 |
| Applications | hCAIX Inhibitor |
| Formula | C18H14N4O3S2 |
| Molecular Weight | 398.46 |
| SMILES | O=S(C1=CC=C(N)C=C1)(NC2=C(C3=NC(C4=CC=CC=C4)=NO3)SC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.