Fig. 1 · Structure
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hCAIX-IN-5
hCAIX Inhibitor
hCAIX-IN-5 is a selective inhibitor of human carbonic anhydrase IX (hCAIX) with a Ki value of 829.1 nM, demonstrating high potency against this target while showing minimal activity against hCAI and hCAII. This compound is valuable in research focused on cancer biology, particularly in studies investigating tumor microenvironments and hypoxia, where hCAIX is often upregulated. Its specificity makes hCAIX-IN-5 an important tool for elucidating the role of carbonic anhydrases in various cellular processes and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2451479-57-3 |
| Applications | hCAIX Inhibitor |
| Formula | C18H12FNO3 |
| Molecular Weight | 309.29 |
| SMILES | O=C(NC1=CC2=C(OC(C=C2)=O)C=C1)/C=C/C3=CC=C(C=C3)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.