Fig. 1 · Structure
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HCAR2 agonist 1
HCAR2 Agonist
HCAR2 Agonist 1 is an allosteric modulator that selectively activates the Gi protein signaling pathway via the HCAR2 receptor. This compound exhibits significant anti-inflammatory activity, demonstrated by its ability to decrease mRNA levels of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and MCP-1. HCAR2 Agonist 1 has been shown to enhance the anti-inflammatory effects of orthosteric agonists in animal models of colitis, making it a valuable tool for research focused on inflammation and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1066676-21-8 |
| Applications | HCAR2 Agonist |
| Formula | C26H28N4O2 |
| Molecular Weight | 428.53 |
| SMILES | CC1=C(C(N[C@H](C)COC2=CC=CC=C2)=O)C=NC3=C(C4=CC=C(C=C4)C(C)C)C=NN13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.