Fig. 1 · Structure
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Hck-IN-1
Nef-Dependent Hck Inhibitor
Hck-IN-1 is a selective Nef-dependent Hck inhibitor that demonstrates an IC50 of 2.8 μM for the Nef:Hck complex, with over 20 μM for Hck alone. This diphenylpyrazolo compound effectively antagonizes HIV-1 Nef, showing potent antiviral activity with an IC50 range of 100-300 nM against wild-type HIV-1 replication. Hck-IN-1 binds to Asn126 in the binding pocket, contributing to its mechanism of action. This compound is essential for research on HIV-1 pathogenesis and therapeutic development targeting Hck signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1473404-51-1 |
| Applications | Nef-Dependent Hck Inhibitor |
| Formula | C16H11ClN6O3S |
| Molecular Weight | 402.81 |
| SMILES | S=C(N1N=C(C2=CC=C([N+]([O-])=O)C=C2)C(/N=N/C3=CC=CC(Cl)=C3)=C1O)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.