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HDAC3/6-IN-2

HDAC3/6 Inhibitor

HDAC3/6-IN-2 is a selective inhibitor of histone deacetylases HDAC3 and HDAC6, exhibiting IC50 values of 0.368 μM and 0.635 μM, respectively. This compound demonstrates significant antitumor activity by promoting apoptosis in cancer cells. Additionally, HDAC3/6-IN-2 reduces the levels of HDAC3 and HDAC6, leading to the upregulation of acetylated histone H3 and α-tubulin, which may enhance therapeutic outcomes for cancers associated with these targets.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2417510-17-7
Applications	HDAC3/6 Inhibitor
Formula	C₄₉H₆₇N₅O₆
Molecular Weight	822.09
SMILES	O=C(NC1=CC=C(N2CCN(C([C@](CC[C@]3(C)CC[C@@]4(C)[C@]5(C)CCC6C(C)(C)C(C(C#N)=C[C@]6(C)C57)=O)(C)C[C@@]3([H])C4=CC7=O)=O)CC2)C=C1)CCCCCCC(NO)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.