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HDAC3-IN-6

HDAC3 Inhibitor

HDAC3-IN-6 is a selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 of 53 nM. This compound effectively induces the expression of PD-L1 in a dose-dependent manner, promoting apoptosis and elevating reactive oxygen species (ROS) production. HDAC3-IN-6 demonstrates significant antitumor efficacy, particularly in colorectal cancer models, making it a valuable tool for research into cancer therapy and immunomodulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3070532-72-5
Applications	HDAC3 Inhibitor
Formula	C₂₃H₂₃N₅O₃
Molecular Weight	417.46
SMILES	O=C(C1=CC=C(CNC(C2=CN=C(C3=CC=C4OC=CC4=C3)N2)=O)C=C1)NNCCC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.