Fig. 1 · Structure
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HDAC6 degrader-1
PROTAC Degrader
HDAC6 degrader-1 is a PROTAC degrader targeting HDAC6, exhibiting a DC50 value of 3.8 nM in MM.1S cells. This compound efficiently induces the degradation of HDAC6 through a bifunctional strategy, linking a ligand for the E3 ligase Pomalidomide with a ligand for the target protein Nexturastat A via a specialized linker. Its application is vital for investigating the role of HDAC6 in cellular processes and potential therapeutic effects in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2439058-23-6 |
| Applications | PROTAC Degrader |
| Formula | C40H45N9O9 |
| Molecular Weight | 795.84 |
| SMILES | O=C(C1=CC=C(CN(CCCCC2=CN(CCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1)NO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.