Fig. 1 · Structure
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HDP 30.1699
α-Amanitin Derivative
HDP 30.1699 is an α-Amanitin derivative that demonstrates significant cross-linking capabilities. This reagent utilizes the cysteine residues of the anti-HER2 THIOMAB antibody for conjugation with a cysteine-reactive linker, forming a compound with a cleavable linker via maleimide chemistry. It is primarily applied in targeted therapeutic research, enabling effective delivery of cytotoxic agents to HER2-expressing cells while minimizing off-target effects.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2004724-36-9 |
| Applications | α-Amanitin Derivative |
| Formula | C61H80N14O19S |
| Molecular Weight | 1345.44 |
| SMILES | O=C([C@]([H])([C@H](C)[C@H](O)CO)NC([C@@]1([H])N(C[C@H](O)C1)C([C@](CC(N)=O)([H])NC([C@](NC(CNC([C@@]([C@@H](C)CC)([H])NC(CNC2=O)=O)=O)=O)([H])CO3=S)=O)=O)=O)N[C@]2([H])CC4=C3NC5=CC(OCC6=CC=C(NC([C@H](C)NC([C@H](C(C)C)NC(CCN7C(C=CC7=O)=O)=O)=O)=O)C=C6)=CC=C54 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.