Fig. 1 · Structure
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HEAL-116
3βHSD1 Inhibitor
HEAL-116 is a potent, selective inhibitor of 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) with an IC50 value of 1.18 μM and a KD of 1.32 μM. This compound effectively inhibits the metabolism of dehydroepiandrosterone (DHEA) and subsequently reduces DHEA-induced target gene expression and cell proliferation. HEAL-116 is applicable in cancer research, particularly in studies related to prostate cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3059767-85-7 |
| Applications | 3βHSD1 Inhibitor |
| Formula | C20H18ClNO4 |
| Molecular Weight | 371.81 |
| SMILES | OC1=CC(OC=C(C2=CC=C(Cl)C(CN3CCOCC3)=C2)C4=O)=C4C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.