Fig. 1 · Structure
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Heclin
E1/E2/E3 Enzyme Inhibitor
Heclin is a selective inhibitor of HECT E3 ubiquitin ligases, effectively targeting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively. This compound is of significant interest for studies focused on the molecular mechanisms underlying gastric cancer. Its ability to modulate ubiquitination pathways makes it a valuable reagent for research into therapeutic strategies and biomarker development in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 890605-54-6 |
| Applications | E1/E2/E3 Enzyme Inhibitor |
| Formula | C17H17NO3 |
| Molecular Weight | 283.32 |
| SMILES | CC(C(C=C1)=CC=C1NC(/C=C/C2=CC=C(CC)O2)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.