Fig. 1 · Structure
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Hemiasterlin
Antimitotic Agent
Hemiasterlin is an antimitotic marine natural product that exerts potent anticancer effects by disrupting microtubule dynamics, leading to cell cycle arrest and apoptosis. Its cytotoxic properties make it suitable for use as a payload in antibody-drug conjugates (ADCs), enhancing targeted delivery of therapeutics. Hemiasterlin is valuable for research focused on cancer biology and the development of novel anticancer strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 157207-90-4 |
| Applications | Antimitotic Agent |
| Formula | C30H46N4O4 |
| Molecular Weight | 526.71 |
| Synonyms | (-)-Hemiasterlin; Milnamide B |
| SMILES | OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CN(C)C2=CC=CC=C12)C)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.