HEMTAC WEE1 degrader-1 is a HSP90-mediated degrader specifically targeting the WEE1 kinase, with an IC50 of 16.76 nM for HSP90 inhibition. This compound facilitates the ubiquitination and subsequent degradation of WEE1, effectively disrupting the G2/M cell cycle checkpoint. It demonstrates significant anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft models, making it a valuable reagent for research applications in AML therapeutics.
HEMTAC WEE1 degrader-1 is a HSP90-mediated degrader specifically targeting the WEE1 kinase, with an IC50 of 16.76 nM for HSP90 inhibition. This compound facilitates the ubiquitination and subsequent degradation of WEE1, effectively disrupting the G2/M cell cycle checkpoint. It demonstrates significant anticancer activity in acute myeloid leukemia (AML) patient-derived xenograft models, making it a valuable reagent for research applications in AML therapeutics.
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