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Henatinib maleate

Multikinase Inhibitor

Henatinib maleate is an orally active multikinase inhibitor that targets vascular endothelial growth factor receptor 2 (VEGFR-2), c-kit, and platelet-derived growth factor receptor (PDGFR). It exhibits potent antitumor activity, with IC50 values of 0.6 nM for VEGFR-2, 3.3 nM for c-kit, and 41.5 nM for PDGFR. Henatinib maleate effectively inhibits VEGFR-2 phosphorylation and disrupts downstream signaling pathways, making it a valuable tool for cancer research and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1239269-52-3
Applications	Multikinase Inhibitor
Formula	C₂₉H₃₃FN₄O₈
Molecular Weight	584.59
SMILES	OC(/C=C\C(O)=O)=O.O=C(/C(C1=C2)=C\C3=C(C4=C(CCCN(C4=O)C[C@H](O)CN5CCOCC5)N3)C)NC1=CC=C2F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.