Fig. 1 · Structure
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Hepta-histidine
Ku70/HTT Inhibitor
Hepta-histidine functions as a selective inhibitor of the Ku70-Huntingtin protein interaction, playing a significant role in neuroprotection. This compound has been shown to reverse morphological abnormalities in primary neurons derived from human induced pluripotent stem cells (hiPSCs) and extend lifespan in the severe Huntington’s disease R6/2 mouse model. Additionally, Hepta-histidine demonstrates the ability to ameliorate DNA damage in vitro, making it a valuable tool for investigating anti-aggregation effects in Tau-associated neurodegenerative disorders, including Alzheimer's and Huntington's diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 64134-31-2 |
| Applications | Ku70/HTT Inhibitor |
| Formula | C42H51N21O8 |
| Molecular Weight | 978.01 |
| SMILES | [C@H](CC1=CN=CN1)(C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CN=CN3)C(N[C@@H](CC4=CN=CN4)C(O)=O)=O)=O)=O)NC([C@H](CC5=CN=CN5)NC([C@H](CC6=CN=CN6)NC([C@H](CC7=CN=CN7)N)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.