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HER2-IN-14

HER2 Inhibitor

HER2-IN-14 is a potent HER2 inhibitor, exhibiting an IC50 value of 18 nM. Additionally, it demonstrates activity against wild-type EGFR with an IC50 of 6.3 μM. This compound is valuable for investigating HER2-mediated signaling pathways and is relevant in the context of cancer research, particularly in studies targeting breast cancer and other HER2-overexpressing malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2414056-35-0
Applications	HER2 Inhibitor
Formula	C₂₆H₂₃ClF₂N₈O₃
Molecular Weight	568.96
SMILES	ClC(C=C1NC2=NC=NC3=C2C(O[C@@H]4C(F)(CN(CC4)C)F)=C(OC)C=C3)=C(C=C1)OC5=CC6=NC=NN6C=N5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.