Fig. 1 · Structure
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Hex
Enolase Inhibitor
Hex is an enolase inhibitor that targets the enzymes ENO2 and ENO1, demonstrating Ki values of 74.4 nM and 269.4 nM, respectively. With IC50s of 0.14 μM for NfENO and 2.1 μM for TbENO, Hex exhibits significant antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites, and Plasmodium berghei ANKA strain. Additionally, Hex has shown anti-tumor effects in models of intracranial tumors, making it a valuable tool for research in parasitology and oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2004714-32-1 |
| Applications | Enolase Inhibitor |
| Formula | C5H10NO5P |
| Molecular Weight | 195.11 |
| SMILES | OP(O)(C1C(N(O)CCC1)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.