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Hexadecanedioic acid-d28

Catalog No.: A53755
Stable Isotope
Hexadecanedioic acid-d28 is a stable isotope-labeled version of hexadecanedioic acid, which is known to be an orally active metabolite from Bacteroides uniformis. This compound functions as an inhibitor of the IRE1α-XBP1s pathway, effectively modulating flipogenesis and ferroptosis. Hexadecanedioic acid-d28 downregulates key targets, including XBP1 and Hrd1, while activating the Nrf2/SLC7A11/GPX4 pathway. It serves as a valuable tool for investigating mechanisms underlying metabolic-associated fatty liver disease and related metabolic disorders.
Hexadecanedioic acid-d28 130348-90-2 Stable Isotope
Grouped product items
Size Price Stock Qty
1mg
$55.00
In stock
5mg
$150.00
In stock
10mg
$250.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionHexadecanedioic acid-d28 is a stable isotope-labeled version of hexadecanedioic acid, which is known to be an orally active metabolite from Bacteroides uniformis. This compound functions as an inhibitor of the IRE1α-XBP1s pathway, effectively modulating flipogenesis and ferroptosis. Hexadecanedioic acid-d28 downregulates key targets, including XBP1 and Hrd1, while activating the Nrf2/SLC7A11/GPX4 pathway. It serves as a valuable tool for investigating mechanisms underlying metabolic-associated fatty liver disease and related metabolic disorders.
Product Information
Catalog NumA53755
FormulaC16H2D28O4
Molecular Weight314.58
CAS Number130348-90-2
SMILESO=C(O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O
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Isotope-Labeled Compounds