Fig. 1 · Structure
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Hexamethylphosphoramide
Polar Aprotic Solvent
Hexamethylphosphoramide is a polar aprotic solvent known for its role as a flame retardant additive. It participates in cytochrome P-450-mediated N-demethylation, resulting in the formation of formaldehyde. Hexamethylphosphoramide has been associated with inducing DNA-protein crosslinks and is implicated in various biological effects, including the development of nasal tumors and reproductive issues. This compound is utilized in toxicology and environmental research to study chemical-induced carcinogenesis and reproductive toxicity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 680-31-9 |
| Applications | Polar Aprotic Solvent |
| Formula | C6H18N3OP |
| Molecular Weight | 179.20 |
| Synonyms | HMPA |
| SMILES | O=P(N(C)C)(N(C)C)N(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.