HexylHIBO is a selective antagonist of group I metabotropic glutamate receptors, specifically mGlu1a and mGlu5a, with dissociation constants (Kbs) of 140 μM and 110 μM, respectively. This compound has shown efficacy in reducing spontaneous excitatory postsynaptic currents (sEPSCs) in rat models. It does not inhibit mGlu2 and mGlu4a receptors, making it a valuable tool for investigating the role of group I mGluRs in neurological research and the pathophysiology of neuropsychiatric disorders.
HexylHIBO is a selective antagonist of group I metabotropic glutamate receptors, specifically mGlu1a and mGlu5a, with dissociation constants (Kbs) of 140 μM and 110 μM, respectively. This compound has shown efficacy in reducing spontaneous excitatory postsynaptic currents (sEPSCs) in rat models. It does not inhibit mGlu2 and mGlu4a receptors, making it a valuable tool for investigating the role of group I mGluRs in neurological research and the pathophysiology of neuropsychiatric disorders.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
