Fig. 1 · Structure
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HexylHIBO
Group I mGluR Antagonist
HexylHIBO is a selective antagonist of group I metabotropic glutamate receptors, specifically mGlu1a and mGlu5a, with dissociation constants (Kbs) of 140 μM and 110 μM, respectively. This compound has shown efficacy in reducing spontaneous excitatory postsynaptic currents (sEPSCs) in rat models. It does not inhibit mGlu2 and mGlu4a receptors, making it a valuable tool for investigating the role of group I mGluRs in neurological research and the pathophysiology of neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 334887-43-3 |
| Applications | Group I mGluR Antagonist |
| Formula | C12H20N2O4 |
| Molecular Weight | 256.30 |
| SMILES | O=C(O)C(N)CC(ON1)=C(CCCCCC)C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.