Fig. 1 · Structure
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Hibifolin
ADA Inhibitor
Hibifolin is a flavonol glycoside known for its inhibitory action on adenosine deaminase (ADA), with a Ki value of 49.92 μM. It demonstrates neuroprotective properties against β-amyloid-induced neurotoxicity, effectively preventing cell death by blocking Aβ-induced caspase-3 and caspase-7 activation. Additionally, Hibifolin induces Akt phosphorylation in cortical neurons and serves as a natural sortase A (SrtA) inhibitor, exhibiting an IC50 of 31.2 μM. Its antibacterial activities include the attenuation of Staphylococcus aureus pathogenic behaviors, such as adhesion, invasion, and biofilm formation, while also enhancing survival rates in pneumonia models in mice and alleviating associated pathological damages.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 55366-56-8 |
| Applications | ADA Inhibitor |
| Formula | C21H18O14 |
| Molecular Weight | 494.36 |
| SMILES | O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=C3C(C(C(O)=C(C4=CC=C(O)C(O)=C4)O3)=O)=C(O)C=C2O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.