Fig. 1 · Structure
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hiCE inhibitor-1
hiCE Inhibitor
hiCE inhibitor-1 is a selective inhibitor of the human intestinal enzyme (hiCE) with a Ki value of 53.3 nM. This sulfonamide derivative demonstrates potential in mitigating the adverse effects of Irinotecan, specifically by reducing drug-induced diarrhea. It serves as an important tool for researchers focusing on gastrointestinal side effects of cancer therapies and may aid in enhancing patient tolerance to chemotherapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2654-68-4 |
| Applications | hiCE Inhibitor |
| Formula | C18H14Cl2N2O4S2 |
| Molecular Weight | 457.35 |
| SMILES | ClC1=CC=C(S(=O)(NC2=CC=C(NS(=O)(C3=CC=C(Cl)C=C3)=O)C=C2)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.