HIF-2a Translation Inhibitor

Catalog No.: A16181

HIF-2a translation inhibitor

HIF-2a Translation Inhibitor

HIF-2a Translation Inhibitor Chemical Structure

CAS NO. 882268-69-1

HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$480.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.81 mL 174.03 mL 348.06 mL
0.5 mM 6.96 mL 34.81 mL 69.61 mL
1 mM 3.48 mL 17.4 mL 34.81 mL
5 mM 0.7 mL 3.48 mL 6.96 mL

*The above data is based on the productmolecular weight 287.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A16181
Actions Inhibitor
M. Wt 287.31
Formula C9H9N3O4S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 882268-69-1
Synonyms N/A
SMILES COC(=O)C1=C(C=CS1)NN=C(C#N)S(=O)(=O)C

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