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HIF-2a Translation Inhibitor

HIF-2a translation inhibitor

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Catalog No. A16181

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
HIF-2a Translation Inhibitor 76 5mg A16181-5
$70.00
HIF-2a Translation Inhibitor 76 10mg A16181-10
$120.00
HIF-2a Translation Inhibitor 76 50mg A16181-50
$480.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).

HIF-2a Translation Inhibitor

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Chemical Information

Catalog Num A16181
Actions Inhibitor
M. Wt 287.31
Formula C9H9N3O4S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 882268-69-1
Synonyms N/A
SMILES COC(=O)C1=C(C=CS1)NN=C(C#N)S(=O)(=O)C

Biological Activity

Description
HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.81 mL 174.03 mL 348.06mL
0.5 mM 6.96 mL 34.81 mL 69.61 mL
1 mM 3.48 mL 17.4 mL 34.81 mL
5 mM 0.7 mL 3.48 mL 6.96 mL

*The above data is based on the productmolecular weight 287.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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