Fig. 1 · Structure
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HIF-PHD-IN-2
PHD Inhibitor
HIF-PHD-IN-2 is a potent inhibitor of prolyl hydroxylase domain (PHD) enzymes, demonstrating IC50 values of less than 100 nM for PHD1, PHD2, and PHD3. This compound effectively stabilizes hypoxia-inducible factor (HIF) under normoxic conditions, making it valuable in research on cellular responses to hypoxia and the regulation of oxygen homeostasis. Applications include studies in cancer biology, ischemia, and metabolic disorders, where modulation of HIF pathways is of interest.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2711720-45-3 |
| Applications | PHD Inhibitor |
| Formula | C17H15N5O3S |
| Molecular Weight | 369.40 |
| SMILES | OC1=C(C=NN1C2=NC=C(NS(=O)(CC)=O)C=C2)C3=CC=C(C#N)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.