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Hit 1

IDE Inhibitor

Hit 1 is an inhibitor of insulin-degrading enzyme (IDE), demonstrating an EC50 of 5.5 μM. This compound has been shown to reduce glucose-stimulated insulin secretion, making it a valuable tool for research into insulin regulation and potential diabetes therapies. Its ability to modulate IDE activity provides insights into metabolic pathways and offers a basis for further explorations in endocrine function and glucose homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2785377-42-4
Applications	IDE Inhibitor
Formula	C₂₂H₂₄N₄O₃S₂
Molecular Weight	456.58
SMILES	O=C(NCCCN1C=CN=C1)CCCC2=CN(C3=CC=CC=C23)S(=O)(C4=CC=CS4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.