Fig. 1 · Structure
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HK-2-IN-1
HK-2 Inhibito
HK-2-IN-1 is a selective inhibitor of Hexokinase 2 (HK-2), a key enzyme involved in glucose metabolism. This compound demonstrates a non-activating effect on the human recombinant HK-2 enzyme and exhibits significant anti-tumor activity by modulating immune cell responses within the tumor microenvironment. HK-2-IN-1 is particularly relevant for research involving various cancer types, including colon, liver, and breast cancer, making it a valuable tool for the study of tumor metabolism and immunotherapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3114833-48-3 |
| Applications | HK-2 Inhibito |
| Formula | C23H16Cl2FN5 |
| Molecular Weight | 452.31 |
| SMILES | ClC(C=C1Cl)=CC=C1CN(C2=CC(F)=CC=C23)N=C3C4=NC(CC5=CC=CC=C5)=NN4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.