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HK2-IN-3

HK2 Inhibitor

HK2-IN-3 is a potent inhibitor of hexokinase 2 (HK2), demonstrating an IC50 value of 56.4 nM. This compound reduces glucose uptake and downregulates the expression of GLUT1 and GLUT4 in oral squamous cell carcinoma (OSCC) models. HK2-IN-3 triggers mitophagy and apoptosis, effectively suppressing tumor growth and angiogenesis in OSCC xenograft mouse models. It is a valuable tool for research focused on the role of HK2 in cancer metabolism and therapy.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2679261-30-2
Applications	HK2 Inhibitor
Formula	C₁₅H₁₁N₃O₄S
Molecular Weight	329.33
SMILES	O=C(N/N=C/C1=C(O)C(O)=C(O)C=C1)C(S2)=NC3=C2C=CC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.