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HLDA-212

Bifunctional Small Molecule

HLDA-212 is a bifunctional small molecule that targets HaloTag-tagged proteins and Aurora kinases A and B (AURKA/B). By forming a stable ternary complex, HLDA-212 inhibits the cell-survival function of Aurora kinases, leading to apoptosis in cancer cells expressing HaloTag. It demonstrates significant antiproliferative activity with a GI50 value of 0.011 μM in 293_HFL cells. This compound is particularly relevant for research into cancers characterized by high levels of HaloTag expression, such as prostate cancer and various hematological malignancies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3077339-88-6
Applications	Bifunctional Small Molecule
Formula	C₇₀H₉₀BrFN₈O₁₉S
Molecular Weight	1478.47
SMILES	CC[C@H](C(N1CCCC[C@H]1C(O[C@H](CCC2=CC=C(OC)C(OC)=C2)C3=CC=CC(OCC(N(C)CCOCCOCCOCCOCCOCCOCCNS(=O)(C4=CC=C(NC5=NC=C(Br)C(NC6=C(C(N)=O)C(F)=CC=C6)=N5)C=C4)=O)=O)=C3)=O)=O)C7=CC(OC)=C(OC)C(OC)=C7

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.