Fig. 1 · Structure
Documents & Downloads
HLI373 dihydrochloride
Hdm2 Inhibitor
HLI373 dihydrochloride is a potent inhibitor of Hdm2, a key regulator of p53 stability and function. By inhibiting the ubiquitin ligase activity of Hdm2, HLI373 dihydrochloride promotes apoptosis in various tumor cell lines, especially those susceptible to DNA-damaging agents. This compound also exhibits antimalarial properties, making it a valuable tool in cancer research and related therapeutic investigations.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1782531-99-0 |
| Applications | Hdm2 Inhibitor |
| Formula | C18H25Cl2N5O2 |
| Molecular Weight | 414.33 |
| SMILES | O=C1N=C2N(C)C3=C(C=CC=C3)C(NCCCN(C)C)=C2C(N1C)=O.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.