Fig. 1 · Structure
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HNMPA-(AM)3
Insulin Receptor Inhibitor
HNMPA-(AM)3 is a selective inhibitor of the insulin receptor tyrosine kinase, designed to permeate cell membranes. It effectively inhibits prothoracicotropic hormone (PTTH) activation of ERK phosphorylation and subsequent ecdysteroidogenesis. This compound demonstrates significant inhibition of ecdysteroid production (IC50 = 14.2 μM) and insulin receptor activity, with an IC50 of 14.2 μM in mosquitoes and 200 μM in mammals, making it a valuable tool for research in endocrinology and metabolic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 120944-03-8 |
| Applications | Insulin Receptor Inhibitor |
| Formula | C20H23O10P |
| Molecular Weight | 454.36 |
| SMILES | CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
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| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.