Fig. 1 · Structure
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HOE 689
Antitumor Agent
HOE 689, an analog of Digitoxin, functions as an antitumor agent by inducing apoptosis in cancer cells. It demonstrates significant cytotoxicity against lung cancer cells, specifically NCI-H460, with an IC50 value of 52 nM. This compound is valuable for investigations into cancer mechanisms and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 33156-28-4 |
| Applications | Antitumor Agent |
| Formula | C29H44O6 |
| Molecular Weight | 488.66 |
| Synonyms | Ramnodigin |
| SMILES | O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@@H]6O[C@H]([C@@H](CC6)O)C)([H])CC3)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.