Fig. 1 · Structure
Documents & Downloads
HPA-12
CERT Inhibitor
HPA-12 is a ceramide transfer protein (CERT) inhibitor that effectively permeates the blood-brain barrier. This small-molecule compound disrupts the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus by binding to the START domain of CERT, resulting in increased intracellular ceramide levels and reduced sphingomyelin synthesis. HPA-12 induces endoplasmic reticulum stress through the GRP78/ATF6/CHOP signaling pathway and promotes mitochondrial autophagy, which can suppress cell proliferation and trigger apoptosis. In preclinical studies, HPA-12 demonstrates substantial efficacy in reducing leukemia burden and prolonging survival in mouse models of acute myeloid leukemia, making it a valuable tool for investigating lipid metabolism in conditions such as acute myeloid leukemia and Alzheimer's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 383418-30-2 |
| Applications | CERT Inhibitor |
| Formula | C22H37NO3 |
| Molecular Weight | 363.53 |
| SMILES | CCCCCCCCCCCC(N[C@@H](CO)C[C@H](O)C1=CC=CC=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.