Fig. 1 · Structure
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HPGDS inhibitor 3
H-PGDS Inhibitor
HPGDS Inhibitor 3 is a potent and orally active inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with an IC50 value of 9.4 nM and an EC50 of 42 nM. This compound demonstrates a favorable pharmacokinetic profile in mouse, rat, and dog models, along with a selective mechanism of action that minimizes CNS toxicity. HPGDS Inhibitor 3 exhibits significant anti-inflammatory activity, making it a valuable tool for research in inflammation and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2255311-93-2 |
| Applications | H-PGDS Inhibitor |
| Formula | C21H27N3O2 |
| Molecular Weight | 353.46 |
| SMILES | CC(O)([C@H]1CC[C@@H](CC1)NC(C2=CC3=CC=C(N=C3N=C2)C4CC4)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.