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HPK1 ligand-Linker Conjugate 1

Target Protein Ligand-linker Conjugate

HPK1 ligand-Linker Conjugate 1 is a synthesized ligand-linker conjugate designed for the development of PROTACs targeting HPK1. This compound serves as a critical component in the synthesis of PROTAC HPK1 Degrader-5, which exhibits significant anti-tumor activity and is characterized by its potency and oral bioavailability. Its applications extend to cell signaling research and targeted protein degradation strategies in cancer therapy studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3061690-80-7
Applications	Target Protein Ligand-linker Conjugate
Formula	C₁₉H₂₁N₃O₇S
Molecular Weight	435.45
SMILES	O=C(C(CC1)N(C2=O)C(C(C=C3)=C2C=C3N(C4)CC[C@H]4COS(C)(=O)=O)=O)NC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.